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Funayama, Tomoo; Yokota, Yuichiro; Suzuki, Michiyo; Sakashita, Tetsuya; Kobayashi, Yasuhiko
JAEA-Review 2014-050, JAEA Takasaki Annual Report 2013, P. 73, 2015/03
Using a collimating heavy-ion microbeam system, we have explored various effects of heavy-ion hit on biological materials. However, there are limitations of the collimating system in the size of the microbeam spot and in the irradiation speed that cannot be overcome in principle. Thus, we started the development of a focusing microbeam system for target-irradiating individual cells more precisely. In this year, we established the protocol for irradiating "actual" cell sample with scanned beam. In the experiment, the HeLa cells were inoculated on a CR-39 film, then place on the sample stage. The microscopic image of cells was analyzed, and the cells were irradiated with scanned neon microbeam. After irradiation, we found the correspondence of the distribution pattern of the ion hit positions and the 
-H2AX foci on cell nuclei, indicating rapid and accurate irradiation of individual cells with the focusing heavy-ion microbeam.
Kamiya, Tomihiro; Yokota, Wataru; Kobayashi, Yasuhiko; Cholewa, M.*; Krochmal, M. S.*; Laken, G.*; Larsen, I. D.*; Fiddes, L.*; Parkhill, G.*; Dowsey, K.*
Nuclear Instruments and Methods in Physics Research B, 181(1-4), p.27 - 31, 2001/07
Times Cited Count：30 Percentile：87.76(Instruments & Instrumentation)no abstracts in English
Kamiya, Tomihiro; Sakai, Takuro; Oikawa, Masakazu*; Sato, Takahiro*; Ishii, Keizo*; Sugimoto, Asuka*; Matsuyama, Shigeo*
International Journal of PIXE, 9(3&4), p.217 - 225, 1999/11
no abstracts in English
Kamiya, Tomihiro; Sakai, Takuro; *; *; Hirao, Toshio
Nuclear Instruments and Methods in Physics Research B, 158(1-4), p.255 - 259, 1999/00
Times Cited Count：6 Percentile：46.7(Instruments & Instrumentation)no abstracts in English
Kamiya, Tomihiro; Sakai, Takuro; *; *; Hirao, Toshio
F-113-'98/NIES, p.60 - 63, 1998/00
no abstracts in English
Kamiya, Tomihiro; ; *; Suda, Tamotsu*; Hirao, Toshio
Nuclear Instruments and Methods in Physics Research B, 130(1-4), p.285 - 288, 1997/00
Times Cited Count：12 Percentile：67.87(Instruments & Instrumentation)no abstracts in English
Kamiya, Tomihiro; ; Suda, Tamotsu*; *
BEAMS 1995: Dai-6-Kai Ryushisen No Sentanteki Oyo Gijutsu Ni Kansuru Shimpojiumu Koen Rombunshu, 0, p.127 - 130, 1995/00
no abstracts in English
Kamiya, Tomihiro; Yuto, Hidenori; Tanaka, Ryuichi
Dai-5-Kai Tandemu Kasokuki Oyobi Sono Shuhen Gijutsu No Kenkyukai Hokokushu, p.116 - 119, 1992/07
no abstracts in English
Kamiya, Tomihiro; *; Tanaka, Ryuichi
Dai-3-Kai Ryushisen No Sentanteki Oyo Gijutsu Ni Kansuru Shimpojiumu, p.453 - 456, 1992/00
no abstracts in English
Kamiya, Tomihiro; *; Minehara, Eisuke; Tanaka, Ryuichi; Odomari, Iwao*
Nuclear Instruments and Methods in Physics Research B, 64, p.362 - 366, 1992/00
Times Cited Count：30 Percentile：91.05(Instruments & Instrumentation)no abstracts in English
Kamiya, Tomihiro; *; Tanaka, Ryuichi
Proc. of the lst Meeting on the Ion Engineering Society of Japan, p.105 - 110, 1992/00
no abstracts in English
M.Koh*; *; *; *; *; *; *; Kamiya, Tomihiro; *; Minehara, Eisuke; et al.
Proceedings of International Workshop on Radiation Effects of Semiconductor Devices for Spasce Application, p.105 - 111, 1992/00
no abstracts in English
Funayama, Tomoo; Yokota, Yuichiro; Sakashita, Tetsuya; Suzuki, Michiyo; Ikeda, Hiroko; Kobayashi, Yasuhiko
no journal, ,
In JAEA-Takasaki, there are two microbeam systems for biological study: collimating heavy-ion microbeam system, and focusing heavy-ion microbeam system. Using the collimating microbeam system, we have carried out the 
cultured-cell studies of heavy-ion hit effect and analysis of bystander effects. Moreover, we have promoted the microbeam studies of small individuals, such as 
, silkworm, and medaka fish. In these studies, we carried out not only researches aimed to explore the effects of heavy-ion radiation, but also the researches of physiological or developmental biology by applying microbeam as the tool of the radio-microsurgery. The focusing microbeam system was developed for overcoming the limitations of the collimating system. Using the system, we developed the experimental system to irradiate cells rapidly and accurately with the scanned microbeam spot of high-energy heavy-ions.
